For those who are both fans of Girl Genius and fans of RPGs, I recommend checking out this adaptation of the Savage Worlds roleplaying system for the unique and dangerous world of Agatha Heterodyne.  Savage Worlds is brilliant.  Girl Genius is brilliant.  Steampunk is brilliant.  This combination of them is pretty brilliant.  Savage Worlds works well with steampunk on its own, but emiricol adds some nice setting-specific touches that make the system very much like the comics.

Thanks to Stargazer for the tip!